| 翻訳と辞書 |
| DNA-Binding Metallo-intercalators ： ウィキペディア英語版 |
DNA-Binding Metallo-intercalators
DNA-binding metallo-intercalators are positively charged, planar, polycyclic, aromatic compounds that unwind the DNA double helix and insert themselves between DNA base pairs.〔Zeglis, Brian M., Valerie C. Pierre, and Jacqueline K. Barton. "Metallo-intercalators and Metallo-insertors." Chemical Communications 44 (2007): 4565. Web. 26 Jan. 2015 .〕 Metallo-intercalators insert themselves between two intact base pairs without expelling or replacing the original nitrogenous bases; the hydrogen bonds between the nitrogenous bases at the site of intercalation remain unbroken.〔〔Gill, Martin R., and Jim A. Thomas. "Ruthenium(ii) Polypyridyl Complexes and DNA-from Structural Probes to Cellular Imaging and Therapeutics - (RSC Publishing)." Chem Soc Rev, n.d. Web. 26 Jan. 2015. .〕〔Pages, Benjamin J., Dale L. Ang, Elise P. Wright, and Janice R. Aldrich-Wright. "Metal Complex Interactions with DNA." Royal Society of Chemistry, n.d. Web. 26 Jan. 2015. .〕 In addition to π-stacking between the aromatic regions of the intercalator and the nitrogenous bases of DNA, intercalation is stabilized by van der Waals, hydrophobic, electrostatic, and entropic interactions.〔 This ability to bind to specific DNA base pairs allows for potential therapeutic applications of metallo-intercalators.
== Synthesis of Metallo-intercalators ==
In the case of Ruthenium intercalators, the general synthesis consists of preparing intercalative ligands followed by their coupling to a Ruthenium metal complex coordinated by specific ancillary ligands.〔Liu, Yun-Jun, Zhen-Hua Liang, Zheng-Zheng Li, Jun-Hua Yao, and Hong-Liang Huang. "Ruthenium(II) Polypyridyl Complexes: Synthesis and Studies of DNA Binding, Photocleavage, Cytotoxicity, Apoptosis, Cellular Uptake, and Antioxidant Activity." DNA and Cell Biology 30.10 (2011): 829-38. Web. 13 Feb. 2015. .〕〔Du, Ke-Jie, Jin-Quan Wang, Jun-Feng Kou, Guan-Ying Li, Li-Li Wang, Hui Chao, and Liang-〕 Examples of prior Ruthenium complexes used as precursors for metallo-intercalators include cis-() and cis-()∙2H2O, which can be synthesized into ()2+, ()2+, ()(ClO4)2, and Ru(phen)2(bfipH)](ClO4)2.〔Vargiu, Attilio V., and Alessandra Magistrato. "Detecting DNA Mismatches with Metallo-Insertors: A Molecular Simulation Study." Inorganic Chemistry. Inorganic Chemistry, n.d. Web. 26 Jan. 2015. .〕〔Raman, Natarajan, and Ramasubbu Rajakumar. "Bis-amide Transition Metal Complexes: Isomerism and DNA Interaction Study." Science Direct, n.d. Web. 26 Jan. 2015. .〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「DNA-Binding Metallo-intercalators」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|